Erythrocytapheresis limits iron accumulation in chronically transfused sickle cell patients
نویسندگان
چکیده
منابع مشابه
Erythrocytapheresis therapy to reduce iron overload in chronically transfused patients with sickle cell disease.
Chelation therapy with deferoxamine is effective in preventing the risk of transfusional iron overload, but treatment failure is common because of noncompliance. To reduce the transfusional iron load, we have evaluated longterm erythrocytapheresis in 14 subjects with sickle cell disease and stroke (11) or other complications (3) as an alternative to simple transfusion. Subjects were treated wit...
متن کاملCardiac iron overload in chronically transfused patients with thalassemia, sickle cell anemia, or myelodysplastic syndrome
The risk and clinical significance of cardiac iron overload due to chronic transfusion varies with the underlying disease. Cardiac iron overload shortens the life expectancy of patients with thalassemia, whereas its effect is unclear in those with myelodysplastic syndromes (MDS). In patients with sickle cell anemia (SCA), iron does not seem to deposit quickly in the heart. Our primary objective...
متن کاملErythrocytapheresis can reduce iron overload and prevent the need for chelation therapy in chronically transfused pediatric patients.
PURPOSE This research was undertaken to determine the advantages, complications, costs, and efficacy of erythrocytapheresis in young pediatric patients who receive chronic erythrocyte transfusion therapy. PATIENTS AND METHODS We retrospectively analyzed data for 10 children who received erythrocytapheresis for an average of 16 months. Erythrocytapheresis was compared to simple transfusion the...
متن کاملExamination of Reticulocytosis among Chronically Transfused Children with Sickle Cell Anemia
Sickle cell anemia (SCA) is an inherited hemolytic anemia with compensatory reticulocytosis. Recent studies have shown that increased levels of reticulocytosis during infancy are associated with increased hospitalizations for SCA sequelae as well as cerebrovascular pathologies. In this study, absolute reticulocyte counts (ARC) measured prior to transfusion were analysed among a cohort of 29 ped...
متن کاملSerum ferritin and total units transfused for assessing iron overload in adults with sickle cell disease.
Blood transfusion therapy usage in sickle cell disease (SCD) is increasing (Drasar et al, 2011) and with this comes the potential for morbidity and mortality associated with the consequent iron overload. Whilst patients treated with regular blood transfusions have their iron indices monitored regularly and are under regular clinical review, patients receiving sporadic blood transfusions can acc...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 1998
ISSN: 0361-8609,1096-8652
DOI: 10.1002/(sici)1096-8652(199809)59:1<28::aid-ajh6>3.0.co;2-1